Amyloid beta (1-42 specific) Mouse Monoclonal Antibody [Clone ID: CA9 3B3]

Specifications

Product Data
Clone Name	CA9 3B3
Applications	ELISA, WB
Recommend Dilution	ELISA: In combination with capturer antiamyloid peptide N-terminal antibody (mAb clone NT 4A2, Cat.-No AM26042PU-N), the antibody can detect Aβ42 in Sandwich ELISA assay. Immunoblotting.
Reactivity	Human, Mouse, Primate, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	KLH conjugated to a short peptide with amino acid sequence corresponding to the C-terminal of beta amyloid peptide 42.
Specificity	This antibody recognizes the C-terminal sequence of beta amyloid peptide 42 and full length beta amyloid peptide 42. The antibody does not cross react with beta amyloid peptide 40 in dot blotting and ELISA. Cross-reactivity to beta amyloid peptide 43 is about 5% in ELISA.
Formulation	0.01M PBS pH7.2 State: Aff - Purified State: Lyophilized purified IgG fraction
Reconstitution Method	Restore with Double distillated water to adjust the final concentration to 1.0 mg/ml.
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Upon receipt, store (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Background	Amyloid beta peptide 42 (Aβ42) is best known for its role in the formation of senile plaques in the brain of patients with Alzheimer’s disease. Aβ42 and Aβ40 are the two major amyloid peptides that are produced after cleavage of amyloid precursor protein by secretases. Aβ42 (42 amino acids) is very fibrillogenic. The beta pleated structure of Aβ42 constituents the initial and key component of the insoluble amyloid fibril in senile plaque. It is widely accepted that Aβ42 contributes to the pathogenesis of Alzheimer’s disease. One proposition is that the deposition of amyloid fibril onto the brain tissue results in Alzheimer’s disease. Another is that the neurotoxicity of Aβ42 oligomer is the cause of the disease.
Reference Data

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