Leptin Receptor (LEPR) (soluble) Mouse Monoclonal Antibody [Clone ID: 2F1]

Specifications

Product Data
Clone Name	2F1
Applications	ELISA, IHC, WB
Recommend Dilution	Immunohistochemistry on frozen sections: The typical starting working dilution is 1:50. Immunohistochemistry on paraffin sections: The typical starting working dilution is 1:50. Immunoassays (coating): The typical starting working dilution is 1:50. Western blot: The typical starting working dilution is 1:50.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	The monoclonal antibody 2F1 reacts with human soluble leptin receptor (sLR) in plasma. It specifically reacts with sLR with a molecular mass of 180kD. The antibody can be used to measure in both free sLR and sLR bound to leptin in plasma.
Formulation	PBS State: Purified State: Liquid Ig fraction Stabilizer: 0.1% bovine serum albumin Preservative: 0.02% sodium azide
Concentration	lot specific
Purification	Protein G
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C.
Gene Name	leptin receptor
Database Link	Entrez Gene 3953 Human UniProt ID P48357
Background	Leptin is a cytokine that is primarily expressed by adipose tissue. Leptin controls food intake by its interaction with the leptin receptor in the brain. Leptin action is mediated and controlled by the leptin receptor, a class I type cytokine receptor. sLR is generated by proteolytic cleavage of membrane-anchored receptors. This indicates that the leptin receptor might have other functions besides transduction. Binding of leptin with sLR increases the bioavailability of leptin in plasma, but also decreases the binding of leptin to membrane bound leptin receptors. For example, when comparing obese and lean individuals, plasma levels of sLR are significantly decreased whereas leptin levels are significantly increased.
Synonyms	LEP-R, OB receptor, HuB219, LEPR, DB, OBR, OB-R
Reference Data

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