Complement C5 (C5) Mouse Monoclonal Antibody [Clone ID: 2952]

Specifications

Product Data
Clone Name	2952
Applications	ELISA, FN, IHC, WB
Recommend Dilution	Immunohistochemistry on frozen sections: The typical starting working dilution is 1:50. Immunohistochemistry on paraffin sections: The typical starting working dilution is 1:50. Functional assays. Immunoassays. Western blot: The typical starting working dilution is 1:50.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	Monoclonal antibody 2952 reacts with a neo-epitope on C5a (des-Arg) that is formed upon cleavage of C5 into C5a and C5b.
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% bovine serum albumin
Concentration	lot specific
Purification	Protein G
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C.
Gene Name	complement component 5
Database Link	Entrez Gene 727 Human UniProt ID P01031
Background	C5 is involved in the activation of the lythic pathway within the complement system which is an important factor in innate immunity. The complement pathways can be divided in the activation pathways and lytic pathway. The activation pathways lead via C3 to the cleavage of the fifth complement component C5. C5a induces smooth muscle contraction, increases vascular permeability, causes degranulation of mast cells and basophils, and release of lysosomal enzymes. In addition C5a stimulates the directed migration of neutrophils, eosinophils, basophils and monocytes. Recent studies indicate the modulation of the acute-phase response in liver and an overall immune response by inducing synthesis of cytokines such as TNF-alpha IL-1beta, IL-6 and IL-8.
Synonyms	CPAMD4, Complement component 5
Reference Data

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