C1S Mouse Monoclonal Antibody [Clone ID: M81]

Specifications

Product Data
Clone Name	M81
Applications	ELISA, FN, IHC, IP, WB
Recommend Dilution	Immunohistochemistry on frozen and paraffin sections: The typical starting working dilution is 1:10. Flow cytometry: The typical starting working dilution is 1:10. Functional assays: Inhibiting C4 binding and activation. Immunoassays. Immunoprecipitation. Western blot: The typical starting working dilution is 1:10.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	Monoclonal antibody M81 reacts with an epitope on human C protein activated C1s, a subcomponent of the first component of C (C1). The epitope recognised by the antibody M81 is domain IV and/or V of the gamma-domain of activated C1s. It blocks C4 activation and C4 binding to activated C1s. The antibody reacts around the binding site of C1s and reacts with both active and inactive C1s.
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% bovine serum albumin
Concentration	lot specific
Purification	Protein G
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C.
Gene Name	complement component 1, s subcomponent
Database Link	Entrez Gene 716 Human UniProt ID P09871
Background	Activated C1s is a glycosylated single-polypeptide zymogen, MW 85 kD. Activation of the proenzyme C1s occurs through cleavage by the active form of C1r. The activated protease, activated C1s, consists of a disulfide-linked H chain and a L chain. Activated C1s is a serine protease and its catalytic site is located in the L chain. Activation of the classical C pathway is triggered by activated C1s which cleaves C4 and C2 to form the C3 convertase, C4bC2a.
Synonyms	C1 esterase, Complement C1s, Complement 1s
Reference Data

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