Protein S (PROS1) Rat Monoclonal Antibody [Clone ID: PS7]
CAT#: AM26230FC-N
Protein S (PROS1) rat monoclonal antibody, clone PS7, FITC
Conjugation: Unconjugated
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CNY 6,656.00
货期*
5周
规格
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Specifications
Product Data | |
Clone Name | PS7 |
Applications | WB |
Recommend Dilution | Flow Cytometry: 1/50. Western blot: 1/50. |
Reactivity | Human |
Host | Rat |
Clonality | Monoclonal |
Specificity | Monoclonal antibody PS7 is specific for human Protein S (PS), a vitamin K-dependent plasma glycoprotein with a molecular weight of approximately 70 kDa. Allows specific detection of cells carrying PS by flow cytometry. |
Formulation | PBS Label: FITC State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 1% BSA Preservative: 0.02% Sodium Azide |
Concentration | lot specific |
Purification | Protein G Chromatography |
Conjugation | FITC |
Storage Condition | Store undiluted at 2-8°C. |
Gene Name | protein S (alpha) |
Database Link | |
Background | In humans, PS is mainly synthesized by hepatocytes. Mature PS has a modular structure consisting of a Gla-domain containing a short aromatic stack, a region sensitive to cleavage by thrombin and factor Xa , 4 epidermal growth factor (EGF)-like domains, and a sex hormone-binding globulin-like region. The biologic function of PS thought to be of primary importance is its ability to enhance Activated Protein C-dependent proteolytic inactivation of factors Va and VIIIa, which are respectively the cofactors in the pro-thrombinase and tenase complexes of the coagulation cascade. In this way, PS plays an important role in regulating thrombin generation, and therefore controlling procoagulant activity. Crucial to the APC-dependent functions of PS is the high-affinity interaction between PS and negatively charged phospholipid surfaces, conferred by calcium-induced folding of the amino-terminal Gla-domain. |
Synonyms | PROS |
Reference Data |
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