Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone ID: 266-6K1]
CAT#: AM26227BT-N
Myeloperoxidase (MPO) mouse monoclonal antibody, clone 266-6K1, Biotin
Conjugation: Unconjugated
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CNY 3,906.00
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Specifications
Product Data | |
Clone Name | 266-6K1 |
Applications | ELISA, WB |
Recommend Dilution | Immunoassay: The antibody can be used as coat and detector. The typical starting working dilution is 1:50. Western blot (1): Samples were subjected to SDS-PAGE and transferred to PVDF membrane (Ref.1). The typical starting working dilution is 1:50. Positive control: Neutrophils, HL-60 cells. Negative control: Erythocytes. Does not work in Immunohistochemistry on paraffin section. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Specificity | This antibody recognizes human myeloperoxidase (MPO), an ~135 glycoprotein expressed in all cells of the myeloid linage. |
Formulation | PBS Label: Biotin State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% BSA Preservative: 0.02% sodium azide |
Concentration | lot specific |
Purification | Protein G Chromatography |
Conjugation | Biotin |
Storage Condition | Store undiluted at 2-8°C. |
Gene Name | myeloperoxidase |
Database Link | |
Background | MPO functions as an α2β2 heteromultimer consisting of two heavy (α) and two light (β) chains of 55 and 15 kDa respectively. MPO is abundantly present in azurophilic granules of polymorphonuclear neutrophils (PMNs). It is an important enzyme used during phagocytic lysis of engulfed foreign particles which takes part in the defense of the organism through production of hypochlorous acid (HOCl), a potent oxidant. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Upon activation of neutrophils, MPO can be rapidly released and as such useful in body fluids as marker for inflammatory status. |
Synonyms | MPO |
Reference Data |
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