PLVAP Mouse Monoclonal Antibody [Clone ID: 174/2]

Specifications

Product Data
Clone Name	174/2
Applications	IF, IHC, WB
Recommend Dilution	Immunohistochemistry on frozen sections. Flow cytometry. Immunflourescence. Western blot. Typical starting working dilution is 1:50.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody reacts with human plasmalemma vesicle associated protein (PLVAP).
Formulation	PBS Label: FITC State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 1% bovine serum albumin Preservative: 0.02% sodium azide
Concentration	lot specific
Purification	Protein G
Conjugation	FITC
Storage Condition	Store at 2 - 8 °C.
Gene Name	plasmalemma vesicle associated protein
Database Link	Entrez Gene 83483 Human UniProt ID Q9BX97
Background	PLVAP is a 60 kDa type II transmembrane glycoprotein which tends to form homodimers. PLVAP is widely expressed in the vasculature of normal tissues. The vascular staining pattern of PLVAP is quite unique among the endothelial cell antigens, since expression of other antigens (like ICAM-1, P-selectin, E-selectin or VCAM-1) is not limited to vascular endothelial cells. PLVAP expression in the vascular endothelial cells of the CNS is lost in association with formation of an intact blood-brain barrier. However, in the endothelium of human brain tumors expression of PLVAP is specifically up-regulated, making it a suitable antiangiogenic target for brain tumor therapy and cerebral edema. Furthermore, PLVAP is expressed in the vasculature of most other human tumors and as such useful as marker for tumor angiogenesis.
Synonyms	Plasmalemma vesicle protein 1, PV1, PV-1, MECA-32 antigen, FELS, Endothelial cell marker, Endothelial cell surface marker, Endothelial Cell Antigen
Reference Data

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