CDK7 Mouse Monoclonal Antibody [Clone ID: IMD-26]

Specifications

Product Data
Clone Name	IMD-26
Applications	IF, IHC, WB
Recommend Dilution	Western Blot: 0.25 μg/ml. Immunohistochemistry on frozen sections: 0.5 μg/ml. Immunocytochemistry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human Cdk7 protein.
Specificity	This antibody reacts to CDK7.
Formulation	1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative. State: Purified State: Lyphilized purified Ig fraction
Reconstitution Method	Restore with 1.2% sodium acetate or neutral PBS.
Concentration	0,1 mg/ml (after reconstitution with PBS)
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at -20°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	cyclin-dependent kinase 7
Database Link	Entrez Gene 1022 Human UniProt ID P50613
Background	CDK-activating kinases (CAKs) are multisubunit proteins that phosphorylate and thus activate certain cyclin-dependent protein kinases in the regulation of cell cycle progression. Cyclin dependent kinase7( CDK7) gene is mapped to chromosome 2p15-cen. CDK7 functions in both cyclin binding and T-loop phosphorylation and that these 2 steps of CDK1 activation are mutually dependent.
Synonyms	CAK1, P39 Mo15, STK1, CDK-activating kinase
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Stem cell - Pluripotency, Transcription Factors
Protein Pathways	Cell cycle, Nucleotide excision repair

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