Calcineurin A (PPP3CA) Mouse Monoclonal Antibody [Clone ID: CC-6]

Specifications

Product Data
Clone Name	CC-6
Applications	IHC, WB
Recommend Dilution	Western Blot: 0.25 - 0.5 μg/ml. Immunohistochemistry on paraffin sections: 0.5 - 1 μg/ml
Reactivity	Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Bovine brain calcineurin
Specificity	This antibody reacts to PPP3CA.
Formulation	1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative. State: Aff - Purified State: Lyphilized purified Ig fraction
Reconstitution Method	Restore with 1.2% sodium acetate or neutral PBS.
Concentration	0,1 mg/ml (after reconstitution with PBS)
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at -20°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	protein phosphatase 3 catalytic subunit alpha
Database Link	Entrez Gene 24674 RatEntrez Gene 5530 Human UniProt ID Q08209
Background	Calcineurin, the Ca(2+)/calmodulin-regulated protein phosphatase, first detected in skeletal muscle and brain, has been found in all cells from yeast to mammals. Calcineurin A alpha (PPP3CA),is located on human chromosomes 4, Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit. Calcineurin regulates bone formation by the osteoblast.
Synonyms	CALNA, CNA, PP2B catalytic subunit, protein phosphatase 2B catalytic subunit alpha
Reference Data
Protein Families	Druggable Genome, Phosphatase
Protein Pathways	Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Axon guidance, B cell receptor signaling pathway, Calcium signaling pathway, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, T cell receptor signaling pathway, VEGF signaling pathway, Wnt signaling pathway

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