CCDC98 (FAM175A) (N-term) Mouse Monoclonal Antibody [Clone ID: ABRA1-01]

Specifications

Product Data
Clone Name	ABRA1-01
Applications	FC, IHC, IP, WB
Recommend Dilution	Flow Cytometry: 1-2 µg/ml. Immunoprecipitation. Western blot (Reducing Conditions). This clone has been described to work in Immunohistochemistry on Paraffin Sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag
Specificity	This monoclonal antibody ABRA1-01 recognizes N-terminal part of ABRA1 (Abraxas, CCDC98), an adaptor protein involved in DNA repair, which migrates as a 45 kDa band on PAAGE under reducing conditions.
Formulation	PBS, pH~7.4 State: Aff - Purified State: Liquid purified Ig fraction (> 95% by SDS-PAGE) Preservative: 15mM Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	family with sequence similarity 175 member A
Database Link	Entrez Gene 84142 Human UniProt ID Q6UWZ7
Background	ABRA1 (Abraxas), also known as CCDC98, is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.
Synonyms	Protein FAM175A, ABRA1, Abraxas
Reference Data

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