EGFR pTyr1016 Mouse Monoclonal Antibody [Clone ID: EM-12]

CAT#: AM12000PU-N

EGFR pTyr1016 mouse monoclonal antibody, clone EM-12, Purified



Need it in bulk or conjugated?
Get a free quote

CNY 4,860.00


货期*
5周

规格
    • 100 ug

Product images

Specifications

Product Data
Clone Name EM-12
Applications FC, IP, WB
Recommend Dilution Flow Cytometry.
Immunoprecipitation.
Western blot: 1 µg/ml.
Positive control: EGF-stimulated A431.
Negative control: Non-stimulated A431.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Synthetic phospho-peptide covering sequence around tyrosine 1016 of human EGFR
Specificity The antibody EM-12 reacts with human EGFR (ErbB1 / HER1) phosphorylated on tyrosine 1016.
Formulation Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
State: Purified
State: Liquid Ig fraction
Concentration lot specific
Purification Protein A chromatography (> 95% pure by SDS-PAGE)
Conjugation Unconjugated
Storage Condition Store the antibody at 2-8°C for up to one month or (in aliquots) at -20°C for longer.
Gene Name epidermal growth factor receptor
Background The oncoprotein EGFR (epidermal growth factor receptor), also known as HER1 / ErbB1, is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis, although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses.
Synonyms Epidermal growth factor receptor, EGF Receptor, erbB-1, c-ErbB-1
Reference Data
Protein Families Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Secreted Protein, Stem cell relevant signaling - JAK/STAT signaling pathway, Transmembrane
Protein Pathways Adherens junction, Bladder cancer, Calcium signaling pathway, Colorectal cancer, Cytokine-cytokine receptor interaction, Dorso-ventral axis formation, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, GnRH signaling pathway, MAPK signaling pathway, Melanoma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Customer Reviews 
Loading...