RIZ1 (PRDM2) (1-347) Mouse Monoclonal Antibody [Clone ID: 33AT1045]

CAT#: AM11041PU-N

RIZ1 (PRDM2) (1-347) mouse monoclonal antibody, clone 33AT1045, Purified



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CNY 6,446.00


货期*
5周

规格
    • 400 ul

Product images

Specifications

Product Data
Clone Name 33AT1045
Applications WB
Recommend Dilution ELISA: 1/1,000.
Western blotting: 1/100-1/500.
ChIP (validated by third-party citation).
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Immunogen Purified recombinant GST fusion protein encoding aa 1-347 of human RIZ1.
Specificity This antibody is specific for RIZ1, it does not recognize the isoform beta (RIZ2).
Formulation PBS containing 0.09% (W/V) Sodium Azide as preservative.
State: Purified
State: Liquid purified Ig fraction.
Concentration lot specific
Purification Protein G Chromatography eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name PR domain 2
Background Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger geneRIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.
Synonyms PR domain zinc finger protein 2, KMT8, RIZ1, RIZ2, MTB-ZF, HUMHOXY1
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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