CD45 (PTPRC) (CD45RB) Mouse Monoclonal Antibody [Clone ID: 2B11 + PD7/26]

Specifications

Product Data
Clone Name	2B11 + PD7/26
Applications	IHC
Recommend Dilution	Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/100-1/200 Pretreatment of deperaffinized tissue with heat-induced epitope retrieval is recommended. Use Polymer anti Mouse/Rabbit IgG as a detection system. Positive Control: Tonsil or lymph node.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	PD7/26/16: Human peripheral blood lymphocytes maintained in T cell growth factor. 2B11: Isolated neoplastic cells from T cell lymphoma.
Specificity	Recognizes CD45/RB (LCA). Cellular Localization: Cell membrane.
Formulation	State: Supernatant State: Tissue Culture Supernatant Stabilizer: 0.2% BSA Preservative: 15mM Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	protein tyrosine phosphatase, receptor type C
Database Link	Entrez Gene 9332 HumanEntrez Gene 5788 Human UniProt ID P08575
Background	CD45 leukocyte common antigen (LCA) belongs to the family of at least four isoforms of membrane glycoproteins (220, 205, 190, 180kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines, normal and malignant non-hematopoietic tissues. The intracellular portion of these molecules have protein phosphatase activity and are involved in regulation of transmembrane signals. Antibody to CD45 is useful in differential identification of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.
Synonyms	PTPRC, Leukocyte common antigen, L-CA, T200
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane

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