TPMT Mouse Monoclonal Antibody [Clone ID: AT2E7]

Specifications

Product Data
Clone Name	AT2E7
Applications	ELISA, WB
Recommend Dilution	ELISA. Western blot (1:1000).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human TPMT (1-245aa) purified from E. coli
Specificity	The antibody recognizes human TPMT. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	thiopurine S-methyltransferase
Database Link	Entrez Gene 7172 Human UniProt ID P51580
Background	TPMT (Thiopurine S-methyltransferase) is a very important enzyme for the metabolizm of thiopurine compounds. TPMT pharmacogenetics has been studied extensively because of its clinical significance. Many patients got benefited from the knowledge of TPMT genotype-phenotype correlation. Also, TPMT activity exhibits autosomal codominant genetic polymorphism, and patients inheriting TPMT-deficiency are at high risk of potentially fatal hematopoietic toxicity.
Synonyms	Thiopurine S-methyltransferase
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Drug metabolism - other enzymes

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.