AKR1C1 (1-323) Mouse Monoclonal Antibody [Clone ID: AT6D10]

Specifications

Product Data
Clone Name	AT6D10
Applications	ELISA, FC, IF, IHC, WB
Recommend Dilution	ELISA. Western blot: 1/1000. Immunohistochemistry on Paraffin Sections: 10 µg/ml. Immunocytochemistry / Immunoflourescence. Flow cytometry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human AKR1C1 (1-323aa) purified from E. coli
Specificity	The antibody recognizes Human AKR1C1 at aa 1-323.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	aldo-keto reductase family 1, member C1
Database Link	Entrez Gene 1645 Human UniProt ID Q04828
Background	The human aldo-keto reductases 1C1 and 1C3 (AKR1C1 and AKR1C3) have major roles in pre receptor regulation of progesterone action. They can both convert progesterone to the less potent efficiencies. AKR1C1 and AKR1C3 also act as 3-ketosteroid reductase, and as such they can convert the most potent androgen 5alpha-DHT into 3beta-andorstandiol, which is an estrogen receptor beta ligand, and into the inactive androgen 3alpha-androstnionl, respectively.
Synonyms	20-alpha-hydroxysteroid dehydrogenase
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Metabolism of xenobiotics by cytochrome P450

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