NQO2 Mouse Monoclonal Antibody [Clone ID: AT1E3]

Specifications

Product Data
Clone Name	AT1E3
Applications	ELISA, WB
Recommend Dilution	ELISA. Western blot (1:250 - 1:500).
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human NQO2 (1-231aa) purified from E. coli
Specificity	The antibody recognizes human and mouse NQO2. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	NAD(P)H quinone dehydrogenase 2
Database Link	Entrez Gene 18105 MouseEntrez Gene 4835 Human UniProt ID P16083
Background	Quinone oxidoreductase (NQO1 and NQO2) are cytosolic proteins that catalyze metabolic redaction of quinines and derivates.NQO2 is inhibited by flavones such as quercetin. Also benzo(a)pyrene is another known inhibitor of NQO2. Even though overlapping substrates specificities have been observed for NQO1 and NQO2, such as for CB1954 activation, significant differences exist in relative affinities for the various substrates.The detoxification role of NQO2 has not been found, and it has no known endogenous biological substrates. However, NQO1 plays an important role in the detoxification of various endogenous and exogenous quinones, including estrogen quinines. Also NQO2 has a melatonin-binding site, which may explain the anti-oxidant role of melatonin related with circadian rhythm.
Synonyms	NMOR2
Reference Data

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