Sumo 2 (SUMO2) Mouse Monoclonal Antibody [Clone ID: AT10F1]

Specifications

Product Data
Clone Name	AT10F1
Applications	ELISA, IF, IHC, WB
Recommend Dilution	ELISA. Western blot (~1/1000). Immunofluorescence (1/250-1/500). Immunohistochemistry on Paraffin embedded tissues (1/50). Flow Cytometry (~5 µg in 106 cells).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human SUMO2 (1-93aa) purified from E. coli
Specificity	The antibody recognizes Human SUMO2/3. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	small ubiquitin-like modifier 2
Database Link	Entrez Gene 6613 Human UniProt ID P61956
Background	SUMO (small ubiquitin-related modifier) is the best-characterized member of a growing family of ubiquitin-related proteins. 8–11 kDa that covalently modify various intracellular proteins. It resembles ubiquitin in its structure, its ability to be ligated to other proteins. SUMO regulates cellular function of a variety of target proteins. SUMO proteins are expressed as their precursor forms. Cleavage of the residues after the ‘GG’ region of these precursors by SUMO-specific proteases in maturation is a prerequisite for subsequent sumoylation. Notably, SUMO2 and SUMO3 precursors have 96% sequence identity, and recent studies have shown protein substrates conjugated with SUMO2 or SUMO3 have similar, if not identical, biological consequences.
Synonyms	SUMO-2, SMT3B, SMT3H2, HSMT3, Sentrin-2, SUMO-3, SMT3 homolog 1, SMT3H1
Reference Data
Protein Families	Druggable Genome

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