ELK1 pSer383 Mouse Monoclonal Antibody [Clone ID: D7H2]

Specifications

Product Data
Clone Name	D7H2
Applications	ELISA
Recommend Dilution	Indirect ELISA: the antibody is reactive to the un-conjugated Serine383 phosphorylated human ELK-1 peptide, and reactive to the serine383 phosphorylated human ELK-1 peptide conjugated with KLH or the peptide-BSA conjugate. The suggested antigen Coating quantity is 1 µg/ml of peptide/or peptide conjugating in pH 9.5 carbonate buffer, 100 µl/well.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Peptide of a phosphorylated fragment of ELK1 (pSer383) conjugated with KLH.
Specificity	Reactive to the un-conjugated serine383 phosphorylated Human ELK-1 peptide fragment, and reactive to the Serine383 phosphorylated Human ELK-1 peptide fragment conjugated to KLH or the peptide- BSA conjugate. Not reactive to KLH or BSA.
Formulation	0.01M PBS, pH 7.0 without preservatives State: Aff - Purified State: Lyophilized purified IgG fraction
Reconstitution Method	Restore with Double distillated water to adjust the final concentration to 1.0 mg/ml.
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Upon receipt, store (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	ELK1, ETS transcription factor
Database Link	Entrez Gene 2002 Human UniProt ID P19419
Background	ELK1 belongs to the EST transcription factor family. Proteins in the family have a unique DNA binding domain that binds to conserved DNA sequences. Phosphorylation of ELK1 at serine 383 and 389 by mitogen-activated protein kinases (MAPKs) activates ELK1. The binding of ELK1 to target sequences is also regulated by its co-factor, serum response factor (SRF), by alternative splicing, and by SUMOylation. ELK1 regulates the transcription of c-fos and genes encoding cytoskeleton proteins, and was found to play a role in longterm memory formation, drug addiction and other neurological disorders.
Synonyms	Elk-1
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Endometrial cancer, ErbB signaling pathway, Focal adhesion, GnRH signaling pathway, Insulin signaling pathway, MAPK signaling pathway, Prion diseases

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