hCG (CGA) Mouse Monoclonal Antibody [Clone ID: TSH-1]

Specifications

Product Data
Clone Name	TSH-1
Applications	ELISA
Recommend Dilution	ELISA: This antibody can be used as Capturer in Sandwich ELISA with our Matched anti-TSH Antibody Mouse anti Human TSH monoclonal antibody, HRP-conjugated, Cat.-No AM09312HR-N. The suggested capturer coating quantity is 4 µg/ml.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human TSH
Specificity	This antibody is reactive to Alpha chain of Human TSH.
Formulation	0.01M PBS, pH 7.2 without preservatives State: Aff - Purified State: Lyophilized purified IgG fraction
Reconstitution Method	Restore with Double distillated water to adjust the final concentration to 1.0 mg/ml.
Concentration	1.0 mg/ml (after reconstitution)
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	glycoprotein hormones, alpha polypeptide
Database Link	Entrez Gene 1081 Human UniProt ID P01215
Background	Thyroid stimulating hormone (TSH), also known as thyrotropin, is secreted from cells in the anterior pituitary called thyrotrophs, finds its receptors on epithelial cells in the thyroid gland, and stimulates that gland to synthesize and release thyroid hormones. TSH is a glycoprotein hormone composed of two subunits which are non covalently bound to one another. The alpha subunit of TSH is also present in two other pituitary glycoprotein hormones, follicle stimulating hormone and luteinizing hormone, and, in primates, in the placental hormone chorionic gonadotropin. Each of these hormones also has a unique beta subunit, which provides receptor specificity. In other words, TSH is composed of alpha subunit bound to the TSH beta subunit, and TSH associates only with its own receptor. Free alpha and beta subunits have essentially no biological activity. TSH has a alpha subunit that is identical to the one in other glycoprotein hormones such as LH, FSH and HCG.
Synonyms	Follitropin alpha chain, Follicle-stimulating hormone alpha chain, FSH-alpha, Lutropin alpha chain, Luteinizing hormone alpha chain, LSH-alpha, LH alpha, Thyrotropin alpha chain, Thyroid-stimulating hormone alpha chain, TSH-alpha, Choriogonadotropin alpha chain, Chorionic gonadotrophin subunit alpha, hCG-alpha
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
Protein Pathways	Autoimmune thyroid disease, GnRH signaling pathway, Neuroactive ligand-receptor interaction

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