C Reactive Protein (CRP) Mouse Monoclonal Antibody [Clone ID: S5G1]

Specifications

Product Data
Clone Name	S5G1
Applications	ELISA, FC, IF, WB
Recommend Dilution	ELISA: This antibody reacts with Human CRP. Immunoblotting (Western): 1/1000. Immunofluorescence: 10 mg/ml. Fluorescence flow cytometry: 10 mg/ml.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified CRP from human pleural fluid.
Specificity	Reactive with Human CRP. No detectable cross-reaction with Human normal serum proteins. Other species not tested.
Formulation	0.01M PBS, pH 7.2 without preservatives. State: Aff - Purified State: Lyophilized purified IgG fraction.
Reconstitution Method	Restore with Double distillated water to adjust the final concentration to 1.0 mg/ml.
Purification	Affinity Chromatography on Protein G.
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	C-reactive protein, pentraxin-related
Database Link	Entrez Gene 1401 Human UniProt ID P02741
Background	C Reactive Protein is a major acute phase reactant synthesized primarily in the liver hepatocytes. It is a pentraxin (cyclic pentameric protein) compound of five identical nonglycosylated subunits of 206 amino acids each (m.w. 24 kDa), that are bound noncovalently to form the physiologic CRP molecule (m.w. 117.5 kDa). C Reactive Protein mediates activities associated with preimmune nonspecific host resistance. It is opsonic, an initiator of the classical complement cascade and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis. Studies have revealed that among other markers of inflammation, CRP shows the strongest association with cardiovascular events. Many clinical studies demonstrated that coronary mortality among patients with unstable angina and elevated CRP is significantly higher comparing with the patients without elevated CRP. Measurements of C reactive protein (hsCRP) in the patients with ischemic heart disease provide a novel method for detecting individuals at high risk of plaque rupture.
Synonyms	PTX1, C Reactive Protein, Pentraxin-related
Reference Data
Protein Families	Secreted Protein

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