HAX1 Mouse Monoclonal Antibody [Clone ID: AT3C5]

Specifications

Product Data
Clone Name	AT3C5
Applications	ELISA, WB
Recommend Dilution	ELISA. Western blot (1:1000 - 1:2000).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human HAX1 (1-279 aa) purified from E. coli
Specificity	The antibody recognizes human HAX-1. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	HCLS1 associated protein X-1
Database Link	Entrez Gene 10456 Human UniProt ID O00165
Background	HAX1 is known to associate with hematopoietic cell-specific Lyn substrate 1 (HS1), one of the substrates of receptor-coupled tyrosine kinases activated during clonal expansion and deletion in lymphoid cells. It also interacts with the product of the polycystic kidney disease 2 (PKD2) gene and with the F-actin-binding protein, cortactin. HAX1 is also reported to bind to hairpin structures in vimentin and DNA polymerase beta mRNAs, so may play a role in mRNA stability and transport. It may also function in promoting cell survival. Defects in HAX1 are the cause of autosomal recessive severe congenital neutropenia 3 (SCN3) also called Kostmann disease.
Synonyms	HAX-1, HS1BP1, HCLS1-associated protein X-1, HS1-associating protein X-1, HS1-binding protein 1
Reference Data

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