Casein Kinase 1 alpha (CSNK1A1) Mouse Monoclonal Antibody [Clone ID: AT2E2]

Specifications

Product Data
Clone Name	AT2E2
Applications	ELISA, WB
Recommend Dilution	ELISA. Western blot (1/1000-1/2000).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human Casein Kinase 1 alpha (1-337 aa) purified from E. coli
Specificity	The antibody recognizes Human Casein Kinase 1 alpha. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	casein kinase 1 alpha 1
Database Link	Entrez Gene 1452 Human UniProt ID P48729
Background	Caseine Kinase 1 alpha belongs to the protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily. CK1 isoforms (alpha, beta, gamma, delta, epsilon) and their splice variants are involved in diverse cellular processes including membrane trafficking, circadian rhythm, cell cycle progression, chromosome segregation, apoptosis and cellular differentiation. Perhaps it can phosphorylate a large number of proteins and is involved in Wnt signaling where it phosphorylates CTNNB1 on Ser45. Caseine kinase 1 alpha also interacts with the Axin complex.
Synonyms	Casein kinase I alpha, CKI-alpha, CK1
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase
Protein Pathways	Hedgehog signaling pathway, Wnt signaling pathway

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