BID (1-195) Mouse Monoclonal Antibody [Clone ID: 4D3]

Specifications

Product Data
Clone Name	4D3
Applications	ELISA, FC, IF, WB
Recommend Dilution	ELISA. Western blot (1/1,000-1/2,000).  Flow Cytometry. Immunofluorescence/Immunocytochemistry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human BID (aa 1-195) purified from E. coli
Specificity	The antibody recognizes Human BID. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	BH3 interacting domain death agonist
Database Link	Entrez Gene 637 Human UniProt ID P55957
Background	BID is a pro-apoptotic Bcl-2 protein containing only the BH3 domain. In response to apoptotic signaling, BID interacts with another Bcl-2 family protein, Bax, leading to the insertion of Bax into the outer mitochondrial membrane. Bax is believed to induce the opening of the mitochondrial voltage-dependent anion channel. This results in the release of cytochrome c and other pro-apoptotic factors from the mitochondria leading to activation of caspases.
Synonyms	p22 BID
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Natural killer cell mediated cytotoxicity, p53 signaling pathway, Pathways in cancer, Viral myocarditis

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