Heat Shock Protein 90 / HSP90 (alpha + beta) Mouse Monoclonal Antibody [Clone ID: 4F10]

Specifications

Product Data
Clone Name	4F10
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western blot (1:1,000 - 1: 2,000). Immunohistochemistry (1:100 - 1:200).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human Hsp90 (1-732 aa) purified from E.coli
Specificity	The antibody recognizes human Hsp90. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	heat shock protein 90kDa alpha family class A member 1
Database Link	Entrez Gene 3320 Human UniProt ID P07900
Background	Hsp90 is a human heat shock protein. In response to adverse change in their environment, cell from all organisms increase the expression of a class of proteins referred to as heat shock or stress protein. The Hsp90, a highly conserved stress-induced protein, is abundantly expressed in most tissues under non-stress conditions and is required for eukaryotic cell viability. Hsp90 is primarily a cytoplasmic protein and its function remains unknown. It exists in a dimeric form and has been observed to bind to several other cellular proteins such as retro-virus kinases, steroid receptor, heme-regulated protein kinase, actin and tubulin.
Synonyms	HSP90AB1, HSP90B, HSPC2, HSPCB, HSP84, HSP-90, HSP-84, Heat shock protein HSP 90-beta, HSP84, HSP-84, HSP90AA1, HSP90A, HSPC1, HSPCA, HSP86, HSP-86, Renal carcinoma antigen NY-REN-38, Heat shock protein HSP 90-alpha, HSP86, HSP-86
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Antigen processing and presentation, NOD-like receptor signaling pathway, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer

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