Eph receptor A2 (EPHA2) Mouse Monoclonal Antibody [Clone ID: 3D7]

Specifications

Product Data
Clone Name	3D7
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western blot (1/500-1/2,000). Immunohistochemistry (1/100-1/200).
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human EphA2 (559-976 aa) purified from E. coli
Specificity	The antibody recognizes Human and Mouse EPHA2. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	EPH receptor A2
Database Link	Entrez Gene 13836 MouseEntrez Gene 1969 Human UniProt ID P29317
Background	The Eph family of receptors is the largest known subfamily of receptor tyrosine kinases (RTK). Eph RTKs and their ligands, the ephrins, are frequently overexpressed in a variety of cancers and tumor cell lines. One Eph family member, EphA2, is also overexpressed in a wide variety of cancers, including breast, small-cell lung and gastrointestinal cancers, melanomas, and neuroblastomas. The ephrin-Eph interactions are important in development, especially in cell-cell interactions involved in nervous system patterning and possibly in cancer.
Synonyms	Ephrin type-A receptor 2, Epithelial cell kinase, Eph receptor A2
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways	Axon guidance

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