SARM (SARM1) (93-292) Mouse Monoclonal Antibody [Clone ID: Sarmy-1]

Specifications

Product Data
Clone Name	Sarmy-1
Applications	IHC, IP
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 10 µg/ml. Immunoprecipitation: 1/200.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human SARM (aa 93-292)
Specificity	This antibody recognizes human SARM.
Formulation	PBS containing 10% Glycerol and 0.02% Sodium Azide as preservative State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C to -70°C for longer. Avoid repeated freezing and thawing.
Gene Name	sterile alpha and TIR motif containing 1
Database Link	Entrez Gene 23098 Human UniProt ID Q6SZW1
Background	Toll-like receptors (TLRs) play an essential role in the detection and elimination of invading microbes. They are type-1 transmembrane receptors, containing extracellular leucine rich repeats and an intracellular Toll/interleukin-1 receptor (TIR) domain. Upon stimulation, these receptors interact with specific TIR domain-containing adaptor proteins. Five such adaptors have been discovered to date, MyD88, Mal (MyD88 adaptor-like)/TIRAP (TIR domain-containing adaptor protein), Trif (TIR-domain-containing adaptor inducing interferon-beta), TRAM (Trif-related adaptor molecule) and SARM (SAM and ARM-containing protein). Different TLRs use different combinations of these adaptors, leading to the activation of common and unique pathways involved in the elimination of the invading microbe.
Synonyms	SARM, SAMD2, KIAA0524
Reference Data

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