MMP3 Mouse Monoclonal Antibody [Clone ID: SB14d]

Specifications

Product Data
Clone Name	SB14d
Applications	ELISA, IHC
Recommend Dilution	ELISA: 1/1,000-1/4,000. Immunohistochemistry (Frozen/Paraffin): 1/1,000-1/2,000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant MMP-3.
Specificity	This antibody is specific for Human MMP-3. Does not cross react to Human MMP-1, MMP-2 or MMP-9.
Formulation	50% Glycerol/50% PBS, pH 7.4 without preservatives. Label: HRP State: Liquid purified Ig fraction. Label: Horseradish Peroxidase
Conjugation	HRP
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	matrix metallopeptidase 3
Database Link	Entrez Gene 4314 Human UniProt ID P08254
Background	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP3 is an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. MMP3 is reported to be implicated in rheumatoid arthritis and some forms of cancer.
Synonyms	Stromelysin-1, SL-1, Matrix metalloproteinase-3, Transin-1, MMP3, STMY1
Reference Data

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