DIABLO Mouse Monoclonal Antibody [Clone ID: 2D12]

Specifications

Product Data
Clone Name	2D12
Applications	ELISA, WB
Recommend Dilution	ELISA: 1/1,000-1/2,000. Western Blot: 1/5,000-1/10,000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody is specific for Human SMAC/DIABLO.
Formulation	100 mM Borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	diablo IAP-binding mitochondrial protein
Database Link	Entrez Gene 56616 Human UniProt ID Q9NR28
Background	SMAC/DIABLO (second mitochondria-derived activator of caspase/direct IAP-binding protein with low PI) is a mitochondrial protein that functions as a regulatory component during apoptosis. It is encoded by a nuclear gene and is subsequently imported into the mitochondria where the N-terminus is removed generating the mature form of the molecule. SMAC/DIABLO has been shown to neutralize the antiapoptotic effect of the inhibitor of apoptosis protein (IAP) family, a major group of apoptosis regulators that have been shown to directly block caspase activity thereby blocking apoptosis. (Ref.1-6)
Synonyms	0610041G12Rik; DIABLO-S; FLJ10537; FLJ25049; SMAC; SMAC3
Reference Data

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