CD71 (TFRC) Mouse Monoclonal Antibody [Clone ID: RVS10]

Specifications

Product Data
Clone Name	RVS10
Applications	FC
Recommend Dilution	Flow Cytometry: 10 µL/10e6 cells.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody is directed against the Human Transferrin Receptor (CD71).
Formulation	PBS containing 0.09% Sodium Azide as preservative. Label: Biotin State: Liquid purified Ig fraction.
Conjugation	Biotin
Storage Condition	Store the antibody undiluted at 2-8°C for one month or in (aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Gene Name	transferrin receptor
Database Link	Entrez Gene 7037 Human UniProt ID P02786
Background	The Transferrin Receptor has been structurally characterized as a sulfide bound dimer of identical glycoprotein subunits of 95 kDa. The transferrin receptor is not present on resting blood lymphocytes. On PBL, the receptor appears after activation. The expression of transferrin receptor is coordinately regulated with cell growth. Present on T and B cell lines. The soluble (or serum) transferrin receptor (sTfR) is a circulating truncated form of the membrane receptor protein; it is an 85 kDa glycoprotein forming in serum a 320 kDa complex with diferric transferrin. The most important clinical use of the sTfR determination is in the differential diagnosis between iron deficiency anaemia and the anaemia of chronic disease. CD71 plays a critical role in cell proliferation by controlling the supply of iron, which is essential for many metabolic pathways, through the binding and endocytosis of transferrin. (Ref.1-4)
Synonyms	TfR1, p90, Transferrin receptor protein 1
Reference Data

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