CD21 (CR2) Mouse Monoclonal Antibody [Clone ID: BB6-11C9.6]

Specifications

Product Data
Clone Name	BB6-11C9.6
Applications	FC, IHC, IP
Recommend Dilution	Flow Cytometry. (Ref.2-3) Immunohistochemistry (Acetone-Fixed, Frozen Tissue Sections only). (Ref.2) Immunoprecipitation. (Ref.2)
Reactivity	Porcine
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody is specific to Porcine CD21 (Mr. 160 kDa). It stains the following percentages of surface immunoglobulin (sIg) positive cells in porcine lymphoid tissues: 92-96% in peripheral blood; 74-98% in mesenteric lymph nodes; 97-100% in ileal Peyer’s patches (ILPP); 93-97% in spleen; and 0% in thymus. The antibody does not stain B cells in cord blood or spleen from pig fetuses (105 days gestation). Does not stain B cells in cord blood or spleen from pig fetuses (105 days gestation).
Formulation	100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	complement component 3d receptor 2
Database Link	Entrez Gene 1380 Human UniProt ID P20023
Background	CD21 also known as complement receptor 2 (CR2), C3d receptor or EBV receptor is a 140 kDa protein. CD21 is a glycosylated type I transmembrane protein consisting of an extracellular face of a series of 15 or 16 CCP domains. CD21 is the receptor for complement components C3d and iC3b as well as the Epstein-Barr virus (EBV) glycoprotein gp350/220. The soluble CD21 (sCD21) was shown to efficiently trigger CD23 signalling pathways in human monocytes. By inducing release of proinflammatory cytokines and upregulating expression of molecules involved in antigen presentation, sCD21 modulates critical monocyte functions that may be relevant to allergic and inflammatory disorders.
Synonyms	Complement receptor type 2, CR2, C3DR, C3d receptor, EBV Receptor, Dendritic Cell Marker
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	B cell receptor signaling pathway, Complement and coagulation cascades, Hematopoietic cell lineage

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