H2-D1 Mouse Monoclonal Antibody [Clone ID: 28-14-8]
CAT#: AM08080LE-N
H2-D1 mouse monoclonal antibody, clone 28-14-8, Low Endotoxin
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CNY 5,984.00
货期*
4周
规格
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Specifications
Product Data | |
Clone Name | 28-14-8 |
Applications | FC |
Recommend Dilution | Flow Cytometry: < / = 1 µg/10e6 cells. Immunohistochemistry on Frozen Tissue Sections. Complement-mediated cytotoxicity. |
Reactivity | Mouse |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | C3H.SW mouse splenocytes. (Ref.1,2) |
Specificity | This antibody is specific to an epitope in the alpha 3 domain of H-2Db. It binds to the alpha 3 domain of H-2Db in the presence or absence of beta 2 microglobulin. (Ref.7,8) It cross reacts with the alpha 3 domain of H-2Ld, but not Kd or Dd, and with H-2Dq and/or Lq. The antibody has been shown to block H-2Ld-specific and H-2Ld-restricted antigen-specific lysis of target cells by cytotoxic T lymphocytes, (Ref.9-11) but it does not block recognition of H-2Ld-positive target cells by Ly-6G2-positive NK cells. (Ref.12). Customer feedback: Clone 28-14-8 does not cross-react with human cells. |
Formulation | PBS without preservatives. State: Low Endotoxin State: Liquid purified Ig fraction. |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
Gene Name | histocompatibility 2, D region locus 1 |
Database Link | |
Background | The 'classical' MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic alpha chains noncovalently associated with the invariant beta 2-Microglobulin. (Ref.3,4) These antigens are expressed on most nucleated cells but expression varies on different cell types. MHC Class I molecules present endogenously synthesized peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. (Ref.5) |
Synonyms | H-2D(B), H2-D1 |
Reference Data |
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