Il2rb Rat Monoclonal Antibody [Clone ID: 5H4]
CAT#: AM08078AC-N
Il2rb rat monoclonal antibody, clone 5H4, APC
Conjugation: Unconjugated Biotin FITC PE
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CNY 5,005.00
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Specifications
Product Data | |
Clone Name | 5H4 |
Applications | FC |
Recommend Dilution | Flow Cytometry: < / = 0.2 µg/10e6 cells. (Ref.1) |
Reactivity | Mouse |
Host | Rat |
Clonality | Monoclonal |
Immunogen | Rat myeloma YB2/0 transfected with truncated mouse IL-2RB cDNA. (Ref.1) |
Specificity | This antibody recognises beta chain (Mr. 90-100 kDa) of the IL-2 Receptor. It does not block IL-2 binding. (Ref.1) |
Formulation | PBS containing 0.09% Sodium Azide as preservative and a stabilizing agent. Label: APC State: Liquid purified Ig fraction. Label: Allophycocyanin |
Concentration | lot specific |
Conjugation | APC |
Storage Condition | Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing. |
Gene Name | interleukin 2 receptor, beta chain |
Database Link | |
Background | The IL-2 receptor is a complex of three distinct polypeptide chains: (i) the alpha chain which binds IL-2 with low affinity; (ii) the beta chain that binds IL-2 with high affinity; and (ii) the common gamma chain (gc) that does not bind IL-2. (Ref.2) The high affinity receptor complex is an alpha/beta/gamma heterotrimer with a Kd of 1.3 x 10e-11 M. (Ref.2) In mouse spleen, CD122 is expresed on ~30% of CD8+ cells and all NK cells, but < 1% of B cells and CD4+ T lymphocytes. In the thymus, its expression is confined to CD4-CD8+ single positive and CD4-CD8- double negative cells. (Ref.4) Cytoplasmic regions of the IL-2R beta chain are involved in IL-2-mediated cellular signaling and, via the interaction of IL-2 and its receptor complex, may be involved in the generation and differentiation of T lymphocytes. (Ref.1,4) |
Synonyms | Interleukin-2 receptor subunit beta, IL-2 receptor subunit beta, IL2 Receptor beta, P70-75 |
Reference Data |
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