Tnfrsf8 Hamster Monoclonal Antibody [Clone ID: mCD30.1]

Specifications

Product Data
Clone Name	mCD30.1
Applications	FC, FN
Recommend Dilution	Flow Cytometry. (Ref.1) Functional Assay: In vitro costimulation of T cells and NK cells. (Ref.1)
Reactivity	Mouse
Host	Hamster
Clonality	Monoclonal
Immunogen	Recombinant mouse CD30 extracellular domain-mouse IgG1 fusion protein. (Ref.1)
Specificity	This antibody is specific to Murine CD30, Mr 52 kDa (core peptide).
Formulation	PBS containing no preservatives. State: Low Endotoxin State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	tumor necrosis factor receptor superfamily, member 8
Database Link	Entrez Gene 21941 Mouse UniProt ID Q60846
Background	CD30 is a type I transmembrane protein and a member of the tumor necrosis factor receptor superfamily of proteins. (Ref.1,2) Murine CD30 is expressed predominantly in the thymus, and it is inducible in mouse splenocytes stimulated with pokeweed mitogen or concanavalin A. (Ref.1) In anti-CD3e-activated spleen cells, CD30 is expressed primarily on the surface of CD8+ T cells with peak expression on days 4 and 5. Stimulation of CD30+ CTL lines with plate-bound anti-CD30 directly signals IL-5 but not IFN-gamma production. (Ref.1) While these studies demonstrate that CD30 directs cytokine secretion and suggest that CD30 may play a pivotal role in the pattern of cytokine production by T cells, the precise roles of CD30 and its ligand (CD153) in T-cell development have not been clearly defined.
Synonyms	TNFRSF8, D1S166E, CD30L receptor, KI-1 antigen
Reference Data

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