Cd8a Rat Monoclonal Antibody [Clone ID: 53-6.7]
CAT#: AM08023LE-N
Cd8a rat monoclonal antibody, clone 53-6.7, Low Endotoxin
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CNY 4,136.00
货期*
4周
规格
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Specifications
Product Data | |
Clone Name | 53-6.7 |
Applications | FN |
Recommend Dilution | Functional Assay: In vivo and in vitro depletion of CD8a+ cells. (Ref. 1,4,5) Fractionation of CD8a+ T cells. (Ref.10) |
Reactivity | Mouse |
Host | Rat |
Clonality | Monoclonal |
Specificity | This antibody recognises the alpha chain of the Murine CD8 hetrerodimer (Mr. 32-34 kDa). In vivo and in vitro treatment with the 53-6.7 monoclonal antibody effectively depletes CD8a+ cells. The 53-6.7 monoclonal antibody also blocks allogeneic help specific for class I MHC antigens and T cell responses to IL-2. (Ref. 1-8) |
Formulation | PBS without preservatives. State: Low Endotoxin State: Liquid purified Ig fraction. |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
Gene Name | CD8 antigen, alpha chain |
Database Link | |
Background | In the mouse, CD8 exists in two forms: (i) a CD8 heterodimer composed of an alpha chain (CD8a/Lyt-2) and a beta chain (CD8b/Lyt-3); and (ii) a homodimer of two alpha chains. The heterodimer is found on the surface of essentially all thymocytes and the ''suppressor/cytotoxic'' subpopulation of mature T lymphocytes. Subsets of intestinal intraepithelial lymphocytes express CD8a without CD8b. It has been suggested that CD8+b- T cells mature extrathymically, while development of the CD8a+b+ population of T cells is thymus-dependent. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC class I-restricted CD8+ T cells. In vivo and in vitro treatment with the 53-6.7 monoclonal antibody effectively depletes CD8a+ cells. The 53-6.7 monoclonal antibody also blocks allogeneic help specific for class I MHC antigens and T cell responses to IL-2. (Ref. 1-8) |
Synonyms | CD8 alpha chain, CD8A, MAL |
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