MSH6 Mouse Monoclonal Antibody [Clone ID: 5B11]

Specifications

Product Data
Clone Name	5B11
Applications	ELISA, FC, IF, WB
Recommend Dilution	Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Immunofluorescence: 1/200 - 1/1000. Flow Cytometry: 1/200 - 1/400.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of human MSH6 expressed in E. Coli.
Specificity	This antibody reacts to CDC2.
Formulation	State: Ascites State: Ascitic fluid containing 0.03% sodium azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	34 kDa
Gene Name	mutS homolog 6
Database Link	Entrez Gene 2956 Human UniProt ID P52701
Background	This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.
Synonyms	DNA mismatch repair protein Msh6, GTBP
Reference Data

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