Caspase 8 (CASP8) Mouse Monoclonal Antibody [Clone ID: 1H11]

CAT#: AM06689SU-N

Caspase 8 (CASP8) mouse monoclonal antibody, clone 1H11, Ascites



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CNY 5,775.00


货期*
5周

规格
    • 100 ul

Product images

Specifications

Product Data
Clone Name 1H11
Applications ELISA, FC, IHC, WB
Recommend Dilution Western Blot: 1/500 - 1/2000.
Immunohistochemistry on paraffin sections: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: 1/10000.
Reactivity Human, Monkey, Mouse, Rat
Host Mouse
Clonality Monoclonal
Immunogen Purified recombinant fragment of human CASP8 expressed in E. Coli.
Specificity This antibody reacts to CASP8.
Formulation State: Ascites
State: Ascitic fluid containing 0.03% sodium azide.
Conjugation Unconjugated
Storage Condition

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Predicted Protein Size 26 kDa
Gene Name caspase 8
Background This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.
Synonyms CASP-8, CASP8, MCH5, CAP4
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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