PSIP1 Mouse Monoclonal Antibody [Clone ID: 6E4]

Specifications

Product Data
Clone Name	6E4
Applications	ELISA, IF, IHC, WB
Recommend Dilution	ELISA: 1/10000. Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000.
Reactivity	Human, Monkey, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of Human PSIP1 expressed in E. Coli.
Specificity	Recognizes PSIP1
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	75 kDa
Gene Name	PC4 and SFRS1 interacting protein 1
Database Link	Entrez Gene 11168 Human UniProt ID O75475
Background	Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. Tissue specificity: Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.
Synonyms	PSIP1, DFS70, LEDGF, PSIP2, PC4 and SFRS1-interacting protein, DFS 70, CLL-associated antigen KW-7
Reference Data

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