CTCF Mouse Monoclonal Antibody [Clone ID: 1D11]

Specifications

Product Data
Clone Name	1D11
Applications	ELISA, WB
Recommend Dilution	ELISA: 1/10000. Western Blot: 1/500 - 1/2000.
Reactivity	Human, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of Human CTCF expressed in E. Coli.
Specificity	Recognizes CTCF
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	83 kDa
Gene Name	CCCTC-binding factor
Database Link	Entrez Gene 10664 Human UniProt ID P49711
Background	This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.Tissue specificity: Ubiquitous. Absent in primary spermatocytes.
Synonyms	CCCTC-binding factor, CTCFL paralog
Reference Data

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