TAB2 Mouse Monoclonal Antibody [Clone ID: 3B5]

Specifications

Product Data
Clone Name	3B5
Applications	ELISA, FC, WB
Recommend Dilution	ELISA: 1/10000. Western Blot: 1/500 - 1/2000. Flow Cytometry: 1/200 - 1/400.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of Human TAB2 expressed in E. Coli.
Specificity	Recognizes TAB2 / MAP3K7IP2
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	80 kDa
Gene Name	TGF-beta activated kinase 1/MAP3K7 binding protein 2
Database Link	Entrez Gene 23118 Human UniProt ID Q9NYJ8
Background	The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.
Synonyms	TAK1-binding protein 2, Tab-2, Mitogen-activated protein kinase kinase kinase 7-interacting protein 2
Reference Data

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