RICTOR Mouse Monoclonal Antibody [Clone ID: 4H5]

Specifications

Product Data
Clone Name	4H5
Applications	ELISA, WB
Recommend Dilution	ELISA: 1/10000. Western Blot: 1/500 - 1/2000.
Reactivity	Human, Monkey, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of Human RICTOR expressed in E. Coli.
Specificity	Recognizes RICTOR
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	192 kDa
Gene Name	RPTOR independent companion of MTOR complex 2
Database Link	Entrez Gene 253260 Human UniProt ID Q6R327
Background	Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian TOR (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals . mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GβL and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, GβL, Sin1 and rictor . The mTOR-rictor complex phosphorylates Ser473 of Akt/PKB in vitro . This phosphorylation is essential for full Akt/PKB activation. Furthermore, an siRNA knockdown of rictor inhibits Ser473 phosphorylation in 3T3-L1 adipocytes . This complex has also been shown to phosphorylate the rapamycin-resistant mutants of S6K1, another effector of mTOR .
Synonyms	KIAA1999, Rapamycin-insensitive companion of mTOR, mAVO3
Reference Data

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