Interleukin 34 (IL34) Mouse Monoclonal Antibody [Clone ID: 1D12]

Specifications

Product Data
Clone Name	1D12
Applications	FC, IF, WB
Recommend Dilution	ELISA: 1/10000. Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. Flow Cytometry: 1/200 - 1/400.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of Human IL34 expressed in E. Coli.
Specificity	Recognizes Interleukin-34 / IL34
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	27.5 kDa
Gene Name	interleukin 34
Database Link	Entrez Gene 146433 Human UniProt ID Q6ZMJ4
Background	Interleukin-34 (IL-34) was identified through a functional screening of a library of secreted proteins after transfection of an embryonic kidney cell line with recombinant cDNAs. Flow cytometry and monocyte viability assays demonstrated increased survival and/or proliferation of monocytes induced by IL-34 and specific binding of IL-34 to CD14+ monocytes. IL-34 is a second ligand to the colony stimulating factor (CSF)-1 receptor in addition to CSF1. Like CSF1, IL-34 stimulates phosphorylation of ERK1 and ERK2 in human monocytes and induces differentiation of bone marrow cells into macrophages. Despite its predicted molecular weight, IL-34 will often run at higher molecular weight in SDS-PAGE.
Synonyms	IL-34, C16orf77
Reference Data

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