DAXX Mouse Monoclonal Antibody [Clone ID: 7A11]

Specifications

Product Data
Clone Name	7A11
Applications	ELISA, FC, IF, WB
Recommend Dilution	Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of human DAXX expressed in E. Coli.
Specificity	This antibody reacts to DAXX.
Formulation	PBS State: Aff - Purified State: Liquid purified Ig fraction Stabilizer: 50% glycerol Preservative: 0,03% sodium azide
Purification	Affinity chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	81 kDa
Gene Name	death-domain associated protein
Database Link	Entrez Gene 1616 Human UniProt ID Q9UER7
Background	DAXX (death-domain associated protein), it is a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.
Synonyms	BING2, DAP6, EAP1
Reference Data

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