RSPO1 Mouse Monoclonal Antibody [Clone ID: 7A6]

Specifications

Product Data
Clone Name	7A6
Applications	WB
Recommend Dilution	ELISA: 1/10000. Western Blot: 1/500 - 1/2000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of R-spondin1 expressed in E. Coli.
Specificity	Recognizes R-Spondin-1
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Aodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	R-spondin 1
Database Link	Entrez Gene 284654 Human UniProt ID Q2MKA7
Background	R-spondin1, also known as RSPO1, CRISTIN3, FLJ40906 is a member of the R-spondin family and a 28.9kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.
Synonyms	R-spondin-1
Reference Data

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