EP300 Mouse Monoclonal Antibody [Clone ID: 7D8A6]

Specifications

Product Data
Clone Name	7D8A6
Applications	WB
Recommend Dilution	ELISA: 1/10000. Western Bloting: 1/500 - 1/2000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of EP300 expressed in E. Coli.
Specificity	Recognizes EP300
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	E1A binding protein p300
Database Link	Entrez Gene 2033 Human UniProt ID Q09472
Background	This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
Synonyms	p300 HAT, KAT3B, Histone acetyltransferase p300
Reference Data

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