MDMX (MDM4) Mouse Monoclonal Antibody [Clone ID: 2D10F4]

Specifications

Product Data
Clone Name	2D10F4
Applications	ELISA, IF, IHC, WB
Recommend Dilution	ELISA: 1/10000.  Western Blot: 1/500 - 1/2000.  Immunofluorescence: 1/200 - 1/1000. Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of Human MDM4 expressed in E. Coli.
Specificity	Recognizes MDM4
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	55 kDa
Gene Name	MDM4, p53 regulator
Database Link	Entrez Gene 4194 Human UniProt ID O15151
Background	MDM4, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2.
Synonyms	MDMX, MDM-4
Reference Data

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