SLC22A1 Mouse Monoclonal Antibody [Clone ID: 8C1A3]

Specifications

Product Data
Clone Name	8C1A3
Applications	ELISA, WB
Recommend Dilution	ELISA: 1/10000. Western Blot: 1/500-1/2000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of SYK (aa296-484) expressed in E. Coli.
Specificity	Recognizes Syk (72 kDa)
Formulation	State: Ascites State: Ascitic fluid Preservative: 0.03% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	solute carrier family 22 member 1
Database Link	Entrez Gene 6580 Human UniProt ID O15245
Background	SYK: spleen tyrosine kinase. Syk (72 kDa) is a non-receptor protein tyrosine kinase that plays an important role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration. SYK is a positive effector of BCR stimulated responses. It couples the B cell antigen receptor (BCR) to the mobilization of calcium ions either through a phosphoinositide 3 kinase dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C gamma dependent pathway, when phosphorylated on Tyr 342 and Tyr 346. Thus the differential phosphorylation of SYK can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ions.
Synonyms	Organic cation transporter 1
Reference Data

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