TNF alpha (TNF) Mouse Monoclonal Antibody [Clone ID: 2A9B9]
CAT#: AM06195PU-N
TNF alpha (TNF) mouse monoclonal antibody, clone 2A9B9, Purified
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CNY 5,346.00
货期*
5周
规格
Specifications
Product Data | |
Clone Name | 2A9B9 |
Applications | WB |
Recommend Dilution | ELISA: 1/10000. Western Blotting: 1/500 - 1/2000. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Recombinant Human TNF-alpha |
Specificity | Recognizes TNF-alpha |
Formulation | PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.03% Sodium Azide. |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Gene Name | tumor necrosis factor |
Database Link | |
Background | TNF-alpha (tumor necrosis factor alpha) is an important cytokine produced by numerous cell types including neutrophils, activated lymphocytes, macrophages and NK cells. It plays a critical role in inflammatory responses and in apoptosis. TNF-alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF-alpha exists as a multimer of two, three, or five non covalently linked units, but shows a single 17 kDa band following SDS PAGE under non reducing conditions. Although it has little effect on many cultured normal human cells, TNF-alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF-alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF-alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex. |
Synonyms | TNF, TNF-a, TNFA, TNFSF2, Cachectin |
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