MERTK Mouse Monoclonal Antibody [Clone ID: 7E5G1]

Specifications

Product Data
Clone Name	7E5G1
Applications	WB
Recommend Dilution	ELISA: 1/10000.  Western Bloting: 1/500 - 1/2000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of MER expressed in E. Coli.
Specificity	Recognizes MER (c-mer proto-oncogene tyrosine kinase).
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	MER proto-oncogene, tyrosine kinase
Database Link	Entrez Gene 10461 Human UniProt ID Q12866
Background	MER (c-mer proto-oncogene tyrosine kinase) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. MER has been identified as a tyrosine kinase potentially involved in the development of glioblastomas. It is expressed at highest levels in ovary, prostate, lung and kidney. Gas6, a growth arrest specific gene, and the related anticoagulation factor Protein S have been identified as ligands for the UFO family of receptors. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
Synonyms	C-mer, MER, Receptor tyrosine kinase MerTK
Reference Data

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