MCL1 Mouse Monoclonal Antibody [Clone ID: 8C6 (8C6D4B1)]

Specifications

Product Data
Clone Name	8C6 (8C6D4B1)
Applications	ELISA, IF, IHC, WB
Recommend Dilution	ELISA: 1/10000.  Western Bloting: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of Human MCL-1 expressed in E. Coli.
Specificity	This monoclonal antibody detected a 37 kDa MCL1 in BCBL-1 cell lysate.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.03% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	myeloid cell leukemia 1
Database Link	Entrez Gene 4170 Human UniProt ID Q07820
Background	Mcl-1 (Myeloid cell leukemia-1) is Bcl-2-related and was identified as an early-induction gene thatincreased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-alpha 1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.
Synonyms	BCL2L3, Bcl-2-like protein 3, mcl1/EAT, EAT, r004
Reference Data

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