Siglec 7 (SIGLEC7) Mouse Monoclonal Antibody [Clone ID: 5-386]

Specifications

Product Data
Clone Name	5-386
Applications	FC, IHC
Recommend Dilution	Flow Cytometry: Use 10 µl of 1/100-1/200 diluted antibody to label 1x10e6 cells in 100 µl. Immunohistochemistry on Frozen Sections: 1/100. Recommended Positive Control: Frozen Tonsil.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Monocyte-derived dendritic cells.
Specificity	This antibody is specific for CDw328.
Formulation	PBS, pH 7.4 containing 0.09% Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Affinity Chromatography on Protein G.
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	sialic acid binding Ig like lectin 7
Database Link	Entrez Gene 27036 Human UniProt ID Q9Y286
Background	CDw328 is a type I transmembrane glycoprotein and member of the Siglec (sialic acid binding Ig-like lectin) family, designated Siglec-7, originally identified as an inhibitory NK cell receptor (NKR) and negative regulator of NK activation, attributed to ITIM recruitment of SHP-1 phosphatase. CDw328 is expressed predominantly by natural killer cells (NK) and to a lesser extent by monocytes and granulocytes and, like Siglec-5 (CD170), has been shown to bind to sialylated ligands of targets through recognition of sialic acid in both the alpha-2,3- and alpha-2,6- glycosidic linkage.
Synonyms	Siglec-7, QA79 membrane protein, p75, D-siglec, CDw328, AIRM1
Reference Data

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